FAQ
Frequently asked questions
What grinding media is used for pharmaceutical wet milling?
Pharmaceutical wet milling and nano milling use metal-free, ultra-low-wear zirconia beads such as Zirconox (ceria-stabilised zirconia, 6.05 g/cm³). They produce tight particle-size distributions without adding metal contamination to the active ingredient.
What bead size is needed for nano milling?
Nano milling below 100 nm typically uses 0.05–0.3 mm beads in a mill with a separator designed to retain them, such as the WAB DYNO®-MILL NPM or ECM-AP. Zirconox is available from Ø 0.05 mm.
Which lab bead mill suits pharmaceutical development?
The WAB DYNO®-MILL Research Lab processes batches from about 100 ml with fully metal-free contact parts; the Multi Lab covers 0.15–1.4 L chambers; the NPM scales nano milling to production.
Why is wet milling used for poorly soluble drugs?
Reducing an active ingredient to submicron or nano size increases its surface area, which improves dissolution rate and bioavailability of poorly water-soluble compounds.
Can you supply pharmaceutical milling media in Australia and New Zealand?
Yes. Email sales@kpm.com.au or call (02) 9672 3222 with your mill type, chamber volume, material and target fineness and we will recommend the grade, size and charge with Australia/New Zealand pricing.